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            Be Agilent Sure in Your Analysis of Host Cell Protein (HCP) Impurities

            Be Agilent Sure in Your Analysis of Host Cell Protein (HCP) Impurities

            To find reliable answers, you need techniques and technologies that give you speed without sacrificing data quality or spectral resolution. Count on Agilent innovations to streamline your workflow and enable accurate, reproducible results.

            Bacterial and mammalian cells are commonly used as host systems for producing human therapeutic proteins. Host cell proteins can pose a safety concern if administered along with the therapeutic compound. Therefore, removal is critical during the purification process.

            Click each icon to learn how Agilent can help at every step of your HCP analysis workflow.

            Sample prep

            Separation

            Columns

            Detection

            Analysis

            Service

            The Agilent AssayMAP Bravo platform automates complex sample preparation for HCP analysis, including enzymatic digestion and peptide fractionation. Its robotic precision improves reproducibility across users and labs. What’s more, it allows users to scale experiments up and down from a few samples to hundreds. Other advantages include:

            • The ability to process 8—96 samples in parallel
            • Precise flow control across the cartridge bed
            • Quantitative binding and elution
            • High-efficiency washing
            • Small elution volumes

            Achieve superior outcomes with the high-performance Agilent 1290 Infinity II LC system, and increase peak capacity for challenging separations with 2D-LC.

            Agilent’s new AdvanceBio Peptide Plus column provides the speed, sensitivity, and efficiency you need to quickly confirm and identify target proteins and peptides.

            The 6545XT AdvanceBio LC/Q-TOF pushes your protein analysis to new levels of performance and reproducibility. Iterative MS/MS allows you to identify low abundant host cell proteins in the presence of high concentration of drug product.

            Advanced data mining and processing tools in the Agilent MassHunter Software suite and protein metrics software help you quickly identify and quantify HCPs.

            You can trust Agilent CrossLab service experts to deliver valuable insights and keep your instruments running at top performance. Our industry-leading services—tailored to meet your needs—include technology refresh, application consulting, repairs, preventive maintenance, compliance verification, and education. Ask us how we can support your laboratory today.

            Everything you need to streamline HCP analysis

            Looking for detailed information on new techniques or innovations? Download application notes and other resources to help you achieve accurate results, every time.

            Learn more

            Featured webinar

            Going Deep with Host Cell Proteins—Rapid Low-level Identification and Quantitation

            Learn how to optimize your HCP workflow, and why iterative MS/MS can help you see lower-level peptides and PTMs. We’ll also explore how to perform targeted, sub-ppm HCP quantitation.

            Register now

            Featured resources for ensuring safety and efficacy

            Application note

            Host Cell Protein Analysis Using Agilent AssayMAP Bravo and 6545XT AdvanceBio LC/Q-TOF

            Read how we:

            • Achieved broad dynamic range and excellent reproducibility
            • Identified spiked-in proteins at single digit ppm levels with high confidence
            • Enabled fast, simple protein identification and semiquantification

            Read now

            On-demand webinar

            Register now

            Make your biopharma workflow more productive

            Designed for multiple biopharma workflows: Agilent 6545XT AdvanceBio LC/Q-TOF system

            Look closer

            Analyze highly complex biotherapeutic molecules: Agilent AdvanceBio columns

            Measure what matters

            Produce answers… not just data: Biologics and small molecule analysis

            Explore now

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            For Research Use Only. Not for use in diagnostic procedures.

            To stay up to date on best practices for biotherapeutic drug
            development and discovery, submit this form.

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